Stoichiometry Distribution of the Nephrin/Nck/WASP Signalsome
نویسندگان
چکیده
Short Abstract – Nephrin is a transmembrane protein essential for the formation of actin-based foot processes in glomerular podocytes. Its cytosolic domain contains three tyrosine motifs which recruit Nck, a SH3-SH3SH3-SH2 protein, upon phosphorylation. SH3 domains of Nck recruit WASP to form the Nephrin/Nck/WASP signalsome by binding the poly-proline motifs in WASP [1]. The multi-valences of the components may provide the signalsome multiple copies of each player and varying stoichiometry. The presence of multiple nephrin in the signalsome may promote nephrin clustering and the oligomerization of WASP may be responsible for the integrity of the actin cytoskeleton. Here, we are investigating the hypothesis.
منابع مشابه
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